Fig. 2
Disease modules split into functionally distinct submodules. a. Gene Ontology (GO) semantic similarity of Biological Process (BP) terms that annotate proteins pairs spaced not further than the indicated hyperbolic distance. b. Same as a but for Cellular Component (CC) terms. c Angular distribution of disease proteins associated with 7 illnesses from our gene-disease association dataset. The coloured backgrounds indicate that one of 6 considered protein classes is over-represented in that angular range (Ubi: proteins involved in ubiquitination/proteolysis, TF: transcription factors, RBP: RNA-binding proteins, Trans: transporters, Skel: constituents of the cytoskeleton, Rec: receptors)