Fig. 3

Structural evolution of the gene co-expression networks of Basal and healthy tissues. a Each column is a different structural measure, namely the mean and standard deviation of the degree, the degree assortativity coefficient (DAC), and the size or number of nodes (in thousands of nodes). b Structural deviation from random of the GCN of each tissue, where random, for each structural measure is taken as the structural value of layer 0, representing co-expression noise. The deviation is the sum of the absolute differences of each layers’ structural value from random. c Relation between the (chromosome) attribute assortativity (AAC), and degree assortativity (DAC) coefficients of the GCN of healthy and Basal tissues. Blue and orange lines are simple regression models of each relation, where shadowed background represents the 95% confidence interval of the model. The black dotted line is the identity line (y=y), and is added for reference