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Table 1 Weighted centrality scores of major targets acting on rheumatoid arthritis

From: An efficient weighted network centrality approach for exploring mechanisms of action of the Ruellia herbal formula for treating rheumatoid arthritis

Compositive compounds

\(\phi ^{DC}\)

\(\phi ^{BC}\)

\(\phi ^{CC}\)

Glycidyl oleate

0.5342

0.0485

0.5581

Glyceryl-2 palmitate

0.5109

0.0517

0.5892

Oleoyl chloride

0.4589

0.0528

0.4706

9-Octadecenoic acid (Z)-, methyl ester

0.4316

0.0525

0.4752

Methyl stearate

0.4446

0.0489

0.4468

Hexadecanoic acid, methyl ester

0.4472

0.0532

0.4656

Hexadecanoic acid, 2,3-bis(acetyloxy)propyl ester

0.4912

0.1413

0.4842

Glyceryl diacetate-2-Oleate

0.4509

0.0517

0.4892

Known RA targets

Nitric oxide synthase

0.4982

0.0565

0.5681

Interleukin-1\(\beta\)

0.4106

0.0493

0.4855

Delta-type opioid receptor

0.5417

0.1199

0.4944

Tumor necrosis factor

0.4626

0.1696

0.4896

Prostaglandin G/H synthase 2

0.4933

0.3967

0.5411

Prostaglandin G/H synthase 1

0.4551

0.5040

0.4794

Growth-regulated alpha protein

0.4126

0.0888

0.5249

C–C chemokine receptor type 5

0.4026

0.0589

0.4609

Interleukin-6

0.4244

0.0671

0.5158

Cannabinoid receptor 2

0.4700

0.0401

0.4352

Putative targets

TNF

0.2705

0.0921

0.0588

CXCL10

0.1728

0.0116

0.5640

IL10

0.1728

0.0125

0.5433

IL6

0.3004

0.0930

0.5402

CXCL1

0.1044

0.0151

0.5432

CXCL8

0.1273

0.0160

0.5439

FOXP3

0.4106

0.0149

0.3748

CCR2

0.3004

0.0161

0.4762

CCR5

0.3004

0.0279

0.4922

IL10

0.1273

0.0145

0.5302

CCL2

0.2495

0.0190

0.4548

IL1B

0.1405

0.0253

0.5838

IL17

0.2495

0.0195

0.5374

IL13

0.2212

0.0252

0.5347

CSF2

0.2905

0.0996

0.5101