Statistical properties of the MetaCore network of protein–protein interactions

Kotelnikova, Ekaterina; Frahm, Klaus M.; Lages, José; Shepelyansky, Dima L.

doi:10.1007/s41109-022-00444-4

Applied Network Science

Table 2 Top 40 CheiRank nodes of the simple MetaCore network

From: Statistical properties of the MetaCore network of protein–protein interactions

\(K^*\)	\(P^(K^)\quad[10^{-2}]\)	\(k^*\)	\(M(K^*)\)	Name	Class	Localization
1	1.1464	1	0.006332	c-Myc	Transcription factor	Nucleus
2	0.8172		0.035667	eIF2C2 (Argonaute-2)	Generic enzyme	Cytoplasm
3	0.6722		−0.174071	IGF2BP3	Generic binding protein	Cytoplasm
4	0.4890		0.680968	Ubiquitin	Generic binding protein	Cytoplasm
5	0.3719		0.110759	SOX9	Transcription factor	Nucleus
6	0.3529	2	-0.028308	p53	Transcription factor	Nucleus
7	0.3373		0.228978	c-Fos	Transcription factor	Nucleus
8	0.3276		0	CUX1 (p110)	Transcription factor	Nucleus
9	0.2989		−0.057557	SP1	Transcription factor	Nucleus
10	0.2770	3	-0.004135	ESR1 (nuclear)	Transcription factor	Nucleus
11	0.2769	4	0.002825	RelA (p65 NF-kB subunit)	Transcription factor	Nucleus
12	0.2534		−0.010911	eIF2C1 (Argonaute-1)	Generic binding protein	Cytoplasm
13	0.2354		0.062046	Androgen receptor	Transcription factor	Nucleus
14	0.2350		−0.045970	Beta-catenin	Generic binding protein	Cytoplasm
15	0.2330		−0.075622	BRD4	Generic binding protein	Nucleus
16	0.2308		0.153950	Oct-3/4	Transcription factor	Nucleus
17	0.2259		−0.001577	PUM2	Generic binding protein	Cytoplasm
18	0.2239		0.188479	EZH2	Generic enzyme	Nucleus
19	0.2193		0.208146	p300	Generic enzyme	Nucleus
20	0.2072		−0.407833	TUG1	RNA	Cytoplasm
21	0.2072		−0.118501	E2F1	Transcription factor	Nucleus
22	0.2062		0	ASCC2	Generic binding protein	Nucleus
23	0.2005		0	LIMR	Generic receptor	Plasma membrane
24	0.1903		0.148471	BRG1	Generic enzyme	Nucleus
25	0.1871	5	0.250910	STAT3	Transcription factor	Nucleus
26	0.1811		0.381258	RBM24	Generic binding protein	Cytoplasm
27	0.1789		0.746981	SUMO-1	Generic binding protein	Nucleus
28	0.1728		0.140357	c-IAP2	Generic binding protein	Cytoplasm
29	0.1699		0.038221	HIF1A	Transcription factor	Nucleus
30	0.1677		0	Zn\(^{2+}\) cytosol	Inorganic ion	Cytosol
31	0.1623		−0.013644	CDK9	Protein kinase	Cytoplasm
32	0.1587		−0.223816	MeCP2	Generic binding protein	Nucleus
33	0.1533		−0.053592	ELAVL1 (HuR)	Generic binding protein	Nucleus
34	0.1497		0.120649	HDAC1	Generic enzyme	Nucleus
35	0.1473		−0.034082	BRD7	Generic binding protein	Nucleus
36	0.1452		0.131956	CREB1	Transcription factor	Nucleus
37	0.1449		0	Zn\(^{2+}\) nucleus	Inorganic ion	Nucleus
38	0.1423		0.096830	SUMO-2	Generic binding protein	Cytoplasm
39	0.1400		−0.051730	BRD2	Protein kinase	Cytoplasm
40	0.1343		0.228824	C/EBPbeta	Transcription factor	Nucleus

These nodes are sorted by descending CheiRank probabilities \(P^*(K^*)\) and consequently by ascending PageRank index \(K^*\). The corresponding name, class and bio-localization of the node is given. The values \(M(K^*)\) of the PageRank magnetization (7) are also given. The node highlighted in bold corresponds to proteins from the subset of the twelve proteins chosen in Table 1 with \(K^*\le 40\). These proteins are ordered by the relative PageRank index \(k^*\)

Back to article page