Table 1 Top 40 PageRank nodes of the simple MetaCore network
From: Statistical properties of the MetaCore network of protein–protein interactions
K | \(P(K)\quad[10^{-2}]\) | k | M(K) | Name | Class | Localization |
|---|---|---|---|---|---|---|
1 | 0.2506 | 0 | H\(^+\) cytosol | Inorganic ion | Cytosol | |
2 | 0.2376 | 0 | Na\(^+\) cytosol | Inorganic ion | Cytosol | |
3 | 0.1741 | \(-\)0.045970 | Beta-catenin | Generic binding protein | Cytoplasm | |
4 | 0.1701 | 1 | −0.028308 | p53 | Transcription factor | Nucleus |
5 | 0.1469 | 0.256018 | c-Src | Protein kinase | Cytoplasm | |
6 | 0.1435 | 0.708154 | mRNA intracellular | RNA | Intracellular | |
7 | 0.1352 | 0 | H\(^+\) extracellular region | Inorganic ion | Extracellular region | |
8 | 0.1189 | 2 | 0.105603 | EGFR | Receptor with enzyme activity | Plasma membrane |
9 | 0.1180 | −0.014278 | DNA | DNA | Nucleus | |
10 | 0.1125 | 3 | −0.004135 | ESR1 (nuclear) | Transcription factor | Nucleus |
11 | 0.1125 | 0 | K\(^+\) extracellular region | Inorganic ion | Extracellular region | |
12 | 0.1056 | 0 | ADP cytoplasm | Compound | Cytoplasm | |
13 | 0.1023 | 4 | 0.250910 | STAT3 | Transcription factor | Nucleus |
14 | 0.0997 | 0.062046 | Androgen receptor | Transcription factor | Nucleus | |
15 | 0.0947 | 0.287801 | Rac1 | RAS superfamily | Cytoplasm | |
16 | 0.0946 | 0 | PO\(_{4}^{3-}\) cytoplasm | Compound | Cytoplasm | |
17 | 0.0940 | 5 | 0.006332 | c-Myc | Transcription factor | Nucleus |
18 | 0.0919 | 6 | 0.360271 | FAK1 | Protein kinase | Cytoplasm |
19 | 0.0899 | 0.962815 | cytosol K\(^+\) \(\rightarrow\) extracellular region K\(^+\) | Reaction | NA | |
20 | 0.0889 | 7 | 0.003377 | ESR2 (nuclear) | Transcription factor | Nucleus |
21 | 0.0884 | 0 | K\(^+\) cytosol | Inorganic ion | Cytosol | |
22 | 0.0849 | 8 | 0.002825 | RelA (p65 NF-kB subunit) | Transcription factor | Nucleus |
23 | 0.0834 | 9 | 0.004567 | ARX | Transcription factor | Cytoplasm |
24 | 0.0828 | 10 | 0.208984 | ITGB1 | Generic receptor | Plasma membrane |
25 | 0.0787 | 11 | 0.548888 | SHP-2 | Protein phosphatase | Cytoplasm |
26 | 0.0776 | 12 | 0.364614 | GRB2 | Generic binding protein | Cytoplasm |
27 | 0.0760 | 0.479956 | PI3K reg class IA (p85) | Generic binding protein | Cytoplasm | |
28 | 0.0759 | −0.114311 | E-cadherin | Generic binding protein | Plasma membrane | |
29 | 0.0754 | 0.757892 | CO\(_2\) + H\(_2\)O \(\rightarrow\) H\(^+\) + HCO\(_{3}^-\) | Reaction | NA | |
30 | 0.0753 | −0.098664 | p21 | Generic binding protein | Nucleus | |
31 | 0.0752 | 0.148707 | Caveolin-1 | Generic binding protein | Cytoplasm | |
32 | 0.0749 | 0.007470 | Ca\(^{2+}\) cytosol | Inorganic ion | Cytosol | |
33 | 0.0744 | 0.381345 | PI3K reg class IA (p85-alpha) | Generic binding protein | Cytoplasm | |
34 | 0.0727 | −0.220751 | Bcl-2 | Generic binding protein | Mitochondrion | |
35 | 0.0720 | 0 | Cl\(^{-}\) intracellular | Inorganic ion | Intracellular | |
36 | 0.0712 | −0.208082 | MDM2 | Generic enzyme | Nucleus | |
37 | 0.0707 | −0.169004 | PTEN | Lipid phosphatase | Cytoplasm | |
38 | 0.0702 | 0.391984 | PPAR-gamma | Transcription factor | Nucleus | |
39 | 0.0698 | 0.031543 | ACTB | Generic binding protein | Cytoplasm | |
40 | 0.0679 | 0 | Acetyl-CoA intracellular | Compound | Intracellular |