Fig. 1

Example of a bipartite multi-layer graph with 6 layers for drug–target prediction problem. The two types of nodes are presented by vertices of different colors: blue nodes represent drugs or ligands, green nodes represent targets. The different layers are presented by edges of different colors: drug–target network is in deep blue (bipartite layer based on the IUPHAR network), drug networks are in light blue and violet, target networks are in light green, grey and brown. Numerical edge labels represent edge weights. New possible interactions in the bipartite layer are represented by dashed edges with question marks