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Table 2 Experimental data sources for concentrations and related literature in PD. The values for modeling the concentrations of individual genes involved in the biochemical pathways of PD were adapted from experimental data listed as references

From: Computational modelling of TNFα related pathways regulated by neuroinflammation, oxidative stress and insulin resistance in neurodegeneration

Protein/gene name Experiment Region Model Concentration References
Control Diseased
TNF α Sandwich enzyme immunoassay (EIA) CSF Humans (in vitro) 22.3 + 9.5 pg/ml 96.3 + 9.1 pg/ml (Mogi et al. 1994)
Glutamate Ion exchange chromatography Blood plasma Humans (in vitro) 34.1 + 11.3 μmol/L 71.7 + 8.5 μmol/L (Iwasaki et al. 1992)
Ca 2+ Fluorometric analysis Substantia nigra pars compacta Sprague-Dawley rats. (in vitro) 0.080 μM 100 μM (Putney and Tomita 2011)
TNFR1 ELISA Blood serum Humans (in vitro) 438.9 ± 171.9 pg/ml 558.5 ± 246.3 pg/ml (de JR de Paula et al. 2009)
αS IMR assay Blood plasma Humans (in vitro) 645.57 pg/ml 1294.9 pg/ml (Oczkowska et al. 2014)
ROS Assay for aconitase activity. Parallel assay of α-KGDH activity and H2O2 generation by α-KGDH Statistics. Brain cortex Guinea Pig (in vitro) 12.7 pmol/min/mg 32 pmol/min/mg (Tretter and Dam-Vizi 2004)
IL-1β ELISA CSF Human (in vitro) 9.409 pg/mL 11.122 pg/mL (Hu et al. 2015)
Tau Sandwich ELISA CSF Human (in vitro) 640 ± 230 pg/ml 720 ± 590 pg/ml (Blennow et al. 1995)