Skip to main content
Fig. 7 | Applied Network Science

Fig. 7

From: Computational modelling of TNFα related pathways regulated by neuroinflammation, oxidative stress and insulin resistance in neurodegeneration

Fig. 7

Relative concentration differences in cellular factors that led to oxidative stress regulated by TNFα in AD and PD. a Relative concentration changes in TNFα, Il-1β, ROS, Aβ, tau, etc. could trigger oxidative stress in AD. The role of oxidative stress in TNFα signalling pathway was modelled and elevations in concentration levels of TNFα, Il-1β, tau and Aβ during AD conditions suggests an increase in microglial activation. Increased tau and calcium have also been noticed with the elevations in concentrations of TNFα and microglial activation. b The increase in TNFα and IL-1β was observed compared to normal conditions. This led to an increased concentration level of ROS. The increased level of caspase 1 with the increase in level of cytochrome c was noted. Both these processes may lead to cell death. Microglial activation was also high in both AD and PD conditions

Back to article page