Skip to main content
Fig. 6 | Applied Network Science

Fig. 6

From: Computational modelling of TNFα related pathways regulated by neuroinflammation, oxidative stress and insulin resistance in neurodegeneration

Fig. 6

Relative protein concentration changes involved in insulin impairment related to AD and PD. a Cellular reactions involved in inflammation and insulin signalling could affect the relative concentrationsof tau, ROS, caspases and Lewy body formation. A gradual decrease in insulin concentration level, an increase in rate of tau hyperphosphorylation, elevations in the concentration levels of caspase 9 and ROS were observed that may lead to cell death. As the concentration rate of the Lewy body increases, the concentration level of inflammation also increased. The increase in inflammation rate was noted as a reason for decrease in the level of insulin. b The concentration levels of αS aggregation and Aβ plaques were higher during the diseased conditions. This may attribute to the elevation in tau hyperphosphorylation and Lewy body concentration levels, perhaps leading to the high ROS production. Elevations in protein aggregation lead to inflammation, oxidative stress and impair insulin signalling during AD and PD conditions

Back to article page