Fig. 6
The evolution of degree of highly connected nodes in the top co-expression layer. Two groups of highly connected nodes are considered: hub nodes and the nodes in the main core of the top co-expression layer. a The hub nodes are defined as the nodes with a degree greater than two standard deviations from the mean (dhub≥μ+2σ). b The core of a network is a well-defined set of highly inter-connected nodes (see for example (Seidman 1983)). For each GCN and each layer, degree distribution of each group is compared to that of a control set of nodes using a Z-test. This control group is obtained by picking at random 100 set of nodes of the same size. The cardinality of the hub sets is 533 and 534 for the healthy and Basal GCNs, respectively; and 141 and 133 in the case of the core