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Fig. 7 | Applied Network Science

Fig. 7

From: Computational intractability law molds the topology of biological networks

Fig. 7

Neutrality of genes under evolutionary pressure. a NEP instances are generated with 0, 25, 50, and 75% of genes being neutral (the Oracle has no opinion on them). A neutral gene may nonetheless end up having a non-zero benefit and/or damage score in an NEP instance depending on its interactivity with non-neutral genes. The bar height represents the average EIS (see Fig. 5). As the pressure increases (i.e. as the percentage of neutral genes decreases), the supremacy of real MINs compared to random analogs (no-hubs (NH), no-leaves(NL) and random (RN) networks) is more pronounced. b A zoomed-in view to the constituent nodes in each b:d ratio range for the Fly simulations. In the real MIN (Fly), as the pressure increases from 75% to 0% of genes being neutral, the utility of leaf genes becomes more pronounced as they dominate the 100:0 and 0:100 slices

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