Skip to main content
Fig. 1 | Applied Network Science

Fig. 1

From: Computational intractability law molds the topology of biological networks

Fig. 1

The majority-leaves minority-hubs (mLmH) topology in biological networks. Each dot represents the percentage of genes in the network having a given degree (number of interacting partners). On average, an overwhelming majority (80%) of leaf genes interact with at most 1-3 other genes, and a small elite minority (6%) of hub genes interact with at least 10 other genes. All networks originate from experimental procedures (i.e. none contains in-silico-inferred interactions), and all interactions are direct and physical. PPI and Regulatory networks are obtained from large-scale experimental studies reported in a single source in the literature, while interactions in database-sourced networks may have originated from more than one source (see SI 2 for details and literature references of each networks). Directed and signed networks are marked with and ± respectively. The direction and sign were assigned at random (coin flip) in undirected/unsigned networks; some interactions in TRRUST are unsigned and hence were also assigned as random. “Degree” in this figure is the sum of in- and out-degrees of a node. Data and source code pertaining of all networks are publicly available in Atiia (2017)

Back to article page