Fig. 3
From: Critical behavior of spatial networks as a model of paracrine signaling in tumorigenesis
Images of tumors from confetti mice at different stages of tumor development. a A benign papilloma that has retained distinct clones with no evidence of intermixing. b In the malignant carcinoma, one clone emerges to dominate in a clonal sweep. c After malignant conversion, new cell clones are generated (red and green cells) which show evidence of clone intermixing. This may facilitate the cell-cell interactions that eventually promote metastasis