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Table 5 Macrophage event parameters used for experiments, unless specified in the text

From: A spatially heterogeneous network-based metapopulation software model applied to the simulation of a pulmonary tuberculosis infection

Parameter

Description

Value (per day)

Source

A M

Rate of activation/deactivation of MR by TA

0.3

(Marino and Kirschner 2004)

H MA

Half-sat value for activation of MR by TA

5E2

Estimated

I

Rate of macrophage infection by BER and BED

0.4

(Marino and Kirschner 2004)

H MI

Half-sat value for macrophage infection

1E6

(Marino and Kirschner 2004)

D MR

Death rate of MR

0.01

(Marino and Kirschner 2004)

D MA

Death rate of MA

0.01

(Marino and Kirschner 2004)

D MI

Standard death rate of MI

0.01

(Marino and Kirschner 2004)

B

Rate of bursting of MI due to BIM

0.25

(Marino and Kirschner 2004)

\(R_{M\_lung}\)

Standard rate of recruitment of MR into lung

400

(Wigginton and Kirschner 2001)

\(R_{M\_lymph}\)

Standard rate of recruitment of MR into lymph

53.465

(Marino et al. 2010)

\(E_{M\_MI}\)

Enhanced rate of recruitment of MR into lung by MI

0.0056

(Marino and Kirschner 2004)

\(E_{M\_MA}\)

Enhanced rate of recruitment of MR into lung by MA

0.04

(Marino and Kirschner 2004)

T M

Rate of translocation of MI along LymphEdge (lung to lymph)

0.25

Estimated