A spatially heterogeneous network-based metapopulation software model applied to the simulation of a pulmonary tuberculosis infection

Applied Network Science

Table 3 Bacterial event parameters used for experiments, unless specified in the text

Parameter	Description	Value (per day)	Source
M _Cap	Maximum number of bacteria that can reside in a macrophage	50	(Marino and Kirschner 2004)
θ	Intracellular bacteria replication sigmoid	2	(Marino and Kirschner 2004)
R _ER	Replication rate of B_ER	0.25	(Wigginton and Kirschner 2001)
R _ED	Replication rate of B_ED	0.005	(Wigginton and Kirschner 2001)
R _IM	Replication rate of B_IM	0.005	Estimated
\(D_{B\_R}\)	Destruction rate of B_ER and B_ED by M_R	1.25E-8	(Marino and Kirschner 2004)
\(D_{B\_A}\)	Destruction rate of B_ER and B_ED by M_A	1.25E-4	Estimated
C	Rate of conversion between B_ED and B_ER	1	Estimated
H _C	Half-sat value of O₂ for conversion between B_ED and B_ER	1	Estimated
λ	Sigmoid value for conversion between B_ED and B_ER	1	Estimated
\(T_{B\_Lung}\)	Rate of translocation of B_ER and B_ED along LungEdge	0.001	Estimated
	(within lung)
\(T_{B\_Blood}\)	Rate of translocation of B_ER and B_ED along BloodEdge	0.05	Estimated
	(lymph to lung)