Skip to main content

Table 3 Bacterial event parameters used for experiments, unless specified in the text

From: A spatially heterogeneous network-based metapopulation software model applied to the simulation of a pulmonary tuberculosis infection

Parameter Description Value (per day) Source
M Cap Maximum number of bacteria that can reside in a macrophage 50 (Marino and Kirschner 2004)
θ Intracellular bacteria replication sigmoid 2 (Marino and Kirschner 2004)
R ER Replication rate of BER 0.25 (Wigginton and Kirschner 2001)
R ED Replication rate of BED 0.005 (Wigginton and Kirschner 2001)
R IM Replication rate of BIM 0.005 Estimated
\(D_{B\_R}\) Destruction rate of BER and BED by MR 1.25E-8 (Marino and Kirschner 2004)
\(D_{B\_A}\) Destruction rate of BER and BED by MA 1.25E-4 Estimated
C Rate of conversion between BED and BER 1 Estimated
H C Half-sat value of O2 for conversion between BED and BER 1 Estimated
λ Sigmoid value for conversion between BED and BER 1 Estimated
\(T_{B\_Lung}\) Rate of translocation of BER and BED along LungEdge 0.001 Estimated
  (within lung)   
\(T_{B\_Blood}\) Rate of translocation of BER and BED along BloodEdge 0.05 Estimated
  (lymph to lung)