Fig. 4

Disease proteins affect signal transduction. a Reference greedy routing (GR) efficiency and hop stretch of the hPIN (Rnd. src-trg pairs) compared to the efficiency (hop stretch) achieved if signals are routed between receptors (Rec) and transcription factors (TF) or between proteins that are neither Recs nor TFs, but that have degrees similar to their counterparts (Control). b Impact on GR efficiency (navigability) dealt by faulty proteins sampled from the set of proteins associated with a DM or from a pool of proteins with similar degrees. The blue dashed line indicates the value of the highest impact (i.e. the most negative) from the latter case. c Frequently used faulty proteins are more likely to be FDA-approved drug targets or potential drug targets than infrequent faulty proteins. P-values are the result of a Fisher’s test comparing the proportion of FDA-approved or potential drug targets in frequent vs infrequent faulty proteins